Scienuk Posted June 15, 2016 Report Share Posted June 15, 2016 Hello, How can glycolysis occur if there is no oxygen present? I understand that if there is no oxygen present, NADH + H^+ cannot be oxidised into NAD^+ which is needed for the link reaction and krebs cycle as oxygen is the terminal electron acceptor during oxidative phosphorylation and therefore the electrons will remain in the integral membrane proteins (electron carriers) in the inner mitochondrial membrane. But isn't NAD^+ needed for glyoclysis as well? so how can glycolysis happen? does it get its NAD^+ from another sources other than oxidative phosphorylation? Reply Link to post Share on other sites More sharing options...
Sandwich Posted June 15, 2016 Report Share Posted June 15, 2016 This image I found on google explains it pretty well. Humans/mammals obviously go down the lactic acid route and don't make ethanol... but yeah with no oxygen there is no Krebs cycle. Anaerobic respiration is a short term fix but not sustainable. Generally a cell already has some NAD+ for the initial glycolysis from aerobic respiration, and then the route it goes down in order to generate more is dependent on the availability of O2. 2 Reply Link to post Share on other sites More sharing options...
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